Stem Cell Therapy to Treat Gut Motility Disorders

Grant number: 1019931 | Funding period: 2012 - 2014

Completed

Abstract

Neurons within the wall of the bowel play an essential role in gut motility. A number of motility disorders are caused by diseased enteric neurons, but there are currently no effective treatments for these diseases. We will use animal models of a pediatric motility disorder to examine whether stem cells implanted into the colon can generate neurons and restore normal motility.

Related publications (3)

Surgical intervention to rescue hirschsprung disease in a rat model

LA Stamp, F Obermayr, L Pontell, HM Young, D Xie, DH Croaker, ZM Song, JB Furness

2015-01-01

Background/Aims Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteric..

Enteric neural progenitors are more efficient than brain-derived progenitors at generating neurons in the colon

Q Findlay, KK Yap, AJ Bergner, HM Young, LA Stamp

2014-10-01

Gut motility disorders can result from an absent, damaged, or dysfunctional enteric nervous system (ENS). Cell therapy is an excit..

Transplanted progenitors generate functional enteric neurons in the postnatal colon

R Hotta, LA Stamp, JPP Foong, SN McConnell, AJ Bergner, RB Anderson, H Enomoto, DF Newgreen, F Obermayr, JB Furness, HM Young

2013-03-01

Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of the enteric nervous system. Many..

University of Melbourne Researchers

John Furness